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pentobarbital will decrease the extent or outcome of tacrolimus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital will lower the extent or impact of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with robust CYP3A4 inducers is just not encou